Metal-iodide-alkali-iodide compounds suitable for use in therapeutics and process for manufacturing them



Patented May 3,1927. I I p I 1,627,359- UNITED STATES P TENT OFFICE.

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1T0 Drawing. Application filed June 28, 1923,8eria1 No. 648,349, and in Germany July 3, 1982.

My invention relates to metal-iodideof being'precipitated by water from their alkali-iodide compounds suitablefor use in solutions in the form of their oxide comtherapeutics and to the process of manupounds, could onlybeprevented by the addifacturing them. I v tion of such an excess of alkali iodides in the The cauterizing action and the property of presence of small amounts of acid, as would no precipitating albumin s of silver preparaprevent the albumin-precipitating action. tions for the treatment of gonorrhea were The therapeutically. effective solutions acthe cause of their being replaced by organic cording to the present invention may be silver preparations. The later proposal to prepared for example as follows:

LU employ solutions of bismuth-iodide-alkalil. 100 grammes bismuth-iodide-potassium- 65 iodides in place of silver-albumin compounds iodide, (Kahlbaum) and cc. lactic acid for obtaining the same therapeutic effects (75%) are dissolved in 100 cc. water. was consequently also based on the idea that l0 grammes bismuth-iodide-p0tassium-- such solutions must not precipitate albumin. iodide,1() grammes potassium iodide and 6 1a For this reason in addition to asmall amount cc. lactic acid (75%) are dissolved in 100, T0 of acid, alkali iodides were added insuchcc. water.- large excess to the bismuth iodide or to its 3. partsof the iodine double salt, 20 alkali iodide double salts, that the mixed salt parts of potassium iodide and 2 cc. lactic solutions produced were prevented from preacid (75%) are dissolved in 100 parts of 20 cipitating albumin, gelatine and the like -in water. v I

contradistinction to the bismuth-alkali- 4. 22.5 parts of the double salt, 5 parts iodide solutions used for analytical purposes. potassium iodide, and 20 parts lactic acid Now I have found thatthis was a wrong (75%) are dissolved in 100 parts of water. conclusion. In contradistinction to silver-' All these solutions are usedin a dilution 2-) preparations, with such solutions, sure and of 1:10 or more without precipitation of 8 7 effective therapeutical efiects can be attained. bismuth oxi-iodide occurring.

I only under the condition that alkali-iodides A comparison of the examples shows that are not added in such an excess as would this success is attained-by continuously dibe suflicient to prevent the albumin precipiminishing the excess in alkali-iodides b cor tating action. Based on numerous clinical respgndmgly increasing the amount 0 acid. 85

experiments, the fact has been ascertained The proportion of alkali iodides and acids that it is just the albumin precipitating to metal iodide and to each other, which solutions'of metal-iodide-alkali-iodide comproduces the condition that without prepounds that exert quite an extraordinarily ventingthe albumin precipitating action the eflicient action, so that they are suitable separatlon of blsmuth oxi-lodide is pre- 00 P be attained within wi e limits without dif- Iodide, copper-i dc-513m not-only for the treatment of gonorrhea, but vented, maybe easily ascertained in each surprisingly also for the treatment oi varicase by a few test-tube tests.

ous other pathological processes. The thera- The solutions of such'saltinixtures ma be peutically effective solutionsin question difalso worked up to ointmen "of a high ther- 40 fer fromthe known bismuth-alkali-iodide apeutical eflect. "As an example the-follow:

solutions used for analytical purposes in the mg may be given: same manner as the previously. proposed 5. 300 parts of an ointment base are solutions, in which the excess of alkali ioworkedup with 500 partsof bismuth-iodide- Y dides prevented the albumin precipitating potassiumsiodide, 5 parts lactic aci (75%) 4 action, by" the feature that separation of and 20 parts of waterto form an ointment. bismuth-oxide-iodide does not occur even I use the term metal idodide compounds. I when the solutions are'greatly diluted. This to include. not: only the l'inple metal iodi ,property'ess'ential for the employment of but also any mstal-iodide-llksli-iodid'e'dou "the solution in them utics can, however, ble salt,- for exam le'fsilver-iodid -p0tassli.d-.

I ficulty independently of the excess of alkaiodide-potlssmm-iodi snd'ftho like? It is line-iodide .by eel the pro rtions bealsoobviousthat 'of metal iodide a I tween alkali iodide an acid. e assum salt mitummay be used from which tio has' therefore also been roved toiodide m statu'mseendi faulty that the property of the bismuth salts ample nitrate mam-am I10 If the metal-iodide compound should be acid, (as for instance in the case of zincpotassium-iodide), this acid reaction has to be taken into account when considering the total amount of acid.

I claim: w

1. Process for the production of therapeutically efiective' solutions of metal-iodidealkali-iodide compounds by the addition of alkali-iodides to metal-iodide compounds in the presence of acids in such proportions that the amount of alkali-iodides, acids, and metal-iodide compound is such that the corresponding mixed salt solutions although capable of precipitatingalbumin and the like, are capable of being brought to a high degree of dilution by the addition of water, without separating out insoluble compounds.

2. A process as set forth in claim 1, in which process organic acids are used as acid addition.

3. A rocess as set forth in claim 1, in which process the acid to be used as an addition consists of lactic acid.

4. Therapeutically effective solutions of metal-iodide-alkali-lodide compounds consisting of a mixture of alkali-iodides, metal iodide compounds and acids, the proportion of alkali iodides and acids to the metal iodide and to each other being such, that without preventing the albumin precipitating action the separation of insoluble-compounds by dilution to a high degree with water is prevented.

5. Therapeutically efiective solutions of metal-lodide-alkali-iodide compounds consisting of a mixture of alkali-iodides, metaliodide compounds and acids, containing alkali-iodide in a smaller amount than would be sufficient to prevent the albumin precipitating action, whilst the proportions between alkali-iodide and acid are chosen in such a manner, that separation of precipitate does not occur, even when the solution is greatly diluted with water.

6. Therapeutically effective solutions of metal-iodide-alkali-iodide compounds consisting of a mixture of alkali-iodides, metaliodide compounds and organic acids.

7. Therapeutically eifective solutions of metal-iodidealkali-iodide compounds consisting of a mixture of alkali iodides, metalio lide compounds and lactic acid.

.' In testimony whereof I have afiixed my signature. HANS TRUTTWIN. 

